As a patent agent and technical advisor with a doctorate degree and a dozen years of scientific research experience, Mona Malik, Ph.D., brings research experience in life sciences to support patent prosecution and litigation as well as technical and scientific guidance. Mona brings noteworthy credentials and experience to patent prosecution and litigation in areas such as pharmaceuticals, genetics, cellular biology and botany. She also supports clients in other science-related fields, immunology/ immunotherapy, biochemistry, virology, oncology and agriculture.
Mona earned a Ph.D. from the University of Cambridge after investigating complex mechanisms of chromosomal gene recombination and gene replacement. She also served as a faculty member and research associate at the University of Pennsylvania. Working in the Department of Pulmonary, Allergy and Critical Care at the School of Medicine, Mona investigated the biochemistry of intracellular signaling pathways in mononuclear phagocytes and uncovered a novel mechanism of monocyte infiltration in the central nervous system of HIV-infected patients. Her results in the fields of immunology, anti-cancer therapy and HIV-treatment were published in leading scientific journals.
Mona’s work as postdoctoral research associate at St Jude Children’s Research Hospital focused on various mechanisms responsible for cell cycle regulation and the repair of DNA lesions induced by anti-cancer therapy. Mona played a critical role in discovering the function of the Tyrosyl-DNA Phosphodiesterase enzyme. This enzyme mediates the repair of DNA-damage induced by DNA Topoisomerase II inhibitors, an important class of anti-cancer drugs. Her work was also seminal in the further development of DNA assays to possibly use mutations of the gene TDP1 as a potential biomarker in cancer therapy.
Mona’s undergraduate degree focused on arid-zone agriculture. She specialized in plant breeding and genetics and developed improved wheat varieties. Mona also studied food technology, soil sciences, plant pathology, animal husbandry, agronomy, entomology and horticulture.
Prior to joining Freeborn, Mona served as Patent Agent & Technical Advisor at Hahn Loeser & Parks LLP and Husch Blackwell LLP.
Honors & Awards
Honors & Awards
- American Association for Cancer Research, Pfizer Scholar in Cancer Research Award, 2001
- British Federation of Women Graduates Award, 1998-99
- Charles Wallace Trust Award, 1998-99
- Raymond and Beverly Sackler Award, 1997-98
- American Association for Cancer Research, Member
- American Society for Microbiology, Member
- Cambridge Commonwealth Society, Fellow
- Genetics Society of America, Member
- University of Cambridge Alumni Association, Life Member
- Speaker, American Society of Hematology Annual Meeting, Atlanta, Georgia, 2007.
- Speaker, American Association for Cancer Research annual meetings, Washington, D.C., and Anaheim, California, 2006 and 2005.
- Speaker, National Cancer Institute, European Organization for Research and Treatment of Cancer, Symposium on Molecular Targets and Cancer Therapeutics, Geneva, Switzerland, 2004.
- Co-author, “An Arrestin-dependent multi-kinase signaling complex mediates MIP-1β/CCL4 signaling and chemotaxis of primary human macrophages,” Journal of Leukocyte Biology, Volume 86, Pages 833-845, 2009.
- Co-author, “Monocyte Migration and LFA-1-Mediated Attachment to Brain Microvascular Endothelia is Regulated by SDF-1alpha through Lyn Kinase,” Journal of Immunology, 181(7), Pages 4632-4637, 2008.
- Co-author, “BCR-ABL1 Alters SDF-1alpha-Mediated Adhesive Responses through the Beta2 Integrin LFA-1 in Leukemia Cells,” Blood, 111(10), Pages 5182-5186, 2008.
- Co-author, “Tyrosyl-DNA Phosphodiesterase (Tdp1) Participates in the Repair of Top2-Mediated DNA Damage,” Proceedings of the National Academy of Sciences of the United States of America, 103(24), Pages 8953-8958, 2006.
- Co-author, “Roles of Non-Homologous End-Joining Pathways in Surviving Topoisomerase II-Mediated DNA Damage,” Molecular Cancer Therapeutics, 5(6), Pages 1405-1414, 2006.
- Co-author, “DNA Repair Functions that Control Sensitivity to Topoisomerase-Targeting Drugs,” Eukaryotic Cell, 3(1), Pages 82-90, 2004.
- Co-author, “DNA Topoisomerase in Cancer Therapy - Present and Future,” Andoh, T., ed., Kluwer Academic, New York, Chapter 6, Pages 109-128, 2003.
- Co-author, “Study of Heritability and Genetic Advances in Wheat Crosses,” Journal of Agriculture Research, 33 (4), Pages 235-239, 1995.